Abstract
The objective of this study is to examine the effect of low-magnitude, high-frequency (LMHF) loading, and anti-osteoporosis medications such as parathyroid hormone (PTH) and bisphosphonates on peri-implant bone healing in an osteoporosis model, and to assess their combined effects on these processes. Thirteen-week-old ovariectomized rats (n = 44) were divided into three groups: PTH, alendronate, and saline. After 3 weeks of drug administration, titanium implants were inserted into the tibiae. Each group was subdivided into two groups: with or without LMHF loading via whole-body vibration (50 Hz at 0.5 g, 15 min per day, 5 days per week). Rats were killed 4 weeks following implantation. Removal torque test, micro-CT analyses (relative gray (RG) value, water = 0, and implant = 100), and histomorphometric analyses (bone-to-implant contact (BIC) and peri-implant bone formation (bone volume/tissue volume (BV/TV))) were performed. Removal torque values and BIC were significantly differed by loading and drug administration (ANOVA). Post hoc analysis showed that PTH-treated groups were significantly higher than the other drug-treated groups. BV/TV was significantly enhanced by PTH administration. In cortical bone, RG values were significantly increased by loading. In trabecular bone, however, RG values were significantly increased by PTH administration. These findings suggest that LMHF loading and PTH can act locally and additively on the bone healing process, improving the condition of implant osseointegration.
Highlights
Increasing human life expectancy has meant that greater consideration needs to be given to oral implantation in patients with systemic diseases
In anti-osteoporosis medications have a beneficial effect on peri- trabecular bone, relative gray (RG) values of the parathyroid hormone (PTH)-treated groups were implant bone healing and implant osseointegration in osteoporo- significantly higher than those of the saline-treated and ALN
This study investigated the osteogenic impact of LMHF loading and anti-osteoporosis medications on peri-implant bone healing and implant osseointegration in an osteoporosis model, and assessed their combined effects on these processes
Summary
Increasing human life expectancy has meant that greater consideration needs to be given to oral implantation in patients with systemic diseases. Osteoporosis is known as one of the systemic risk factors for implant failure,[1,2] if without proper management, poor bone quality can result in the lack of primary stability, and impaired bone formation and healing can make achieving osseointegration difficult. Low-magnitude, high-frequency (LMHF) loading, in which a low-magnitude is generally meant as
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