Effect of high volume hemofiltration on organ function and arterial oxygenation in patients with severe septic shock

Abstract

Objective To observe the effect of high-volume hemofiltration (HVHF) on organ function and arterial oxygenation in patients with severe septic shock. Methods The clinical data of 137 patients with severe septic shock treated in Dezhou People’s Hospital from January 2016 to September 2018 were retrospectively analyzed. The 42 patients treated by conventional fluid resuscitation therapy were considered as group A, 45 patients treated by HVHF after 6 hours of fluid resuscitation therapy were considered as group B, and 50 patients treated by HVHF within 6 hours of fluid resuscitation therapy were considered as group C. The changes of functional indexes, including alanine transaminase (ALT), and blood urea nitrogen (BUN) and arterial oxygenation before and after treatment in the three groups were observed. Results There was no significant difference in the levels of ALT, BUN or oxygenation index among group A, group B and group C before treatment (P>0.05). After treatment, compared with group A, the levels of ALT and BUN were lower in group B and group C, and the oxygenation index was higher, and the differences were significant(P<0.05). After treatment, compared with group B, the levels of ALT and BUN were lower and oxygenation index was higher in group C, and the differences were significant (P<0.05). Conclusions HVHF treatment in patients with severe septic shock is conductive to improving arterial oxygenation index and promoting organ function recovery, and early HVHF treatment is more effective. Key words: Septic shock; High volume hemofiltration; Organ function; Arterial oxygenation index