Abstract
In order to decrease the analysis time of a given chromatographic system, many parameters may need to be changed. These changes can adversely affect the chromatographic performance: in particular, the peak capacity may decrease. The peak capacity is a measure of the number of components that can be resolved in a given time. Using this definition of the peak capacity, various options to obtain shorter analysis times were investigated. It was found that such parameters as particle size, column diameter, mobile phase velocity and column length can be changed so that the analysis time decreases without loss of peak capacity. Optimum procedures for that purpose are given. In the course of the analysis, a new efficiency criterion—the rate of peak capacity production—is defined and examined.
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