Abstract
Polylactic acid (PLA) nanoparticles could provide extended release of drugs, reducing the frequency of injection and increasing the compliance diabetic retinopathy patients. This requires nanoparticles with a mean diameter of approximately 200 nm to facilitate penetration of small and narrow blood vessels in the retina. Mean diameter of PLA particles prepared using the emulsification-evaporation method was found to depend linearly on the speed of the high speed homogenizer, based on the data taken in the range of 1,000-10,000 rpm. PLA nanoparticles with a mean particle diameter of 190 nm with a spherical morphology could be obtained using a homogenizer speed of 10,000 rpm, allowing the use of PLA nanoparticles for extended release of drugs in the retina.
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