Effect of high performance chicory inulin on constipation

Abstract

It is known that chicory inulin (average degree of polymerisation DP=10) and oligofructose (DP=4) affect bowel function. Whereas transit time is not affected with daily doses ranging between 4 and 15g, such doses increase stool frequency and have a faecal bulking effect in healthy volunteers. Recently a new type of chicory inulin with higher average chain length (DP=25) has become commercially available. From a nutritional point of view this is an interesting carbohydrate, as it is fermented more slowly than the native product, giving it the opportunity to arrive in more distal parts of the colon. In this placebo controlled study, we investigated the effect of this high performance inulin on bowel function in healthy volunteers with low stool frequency (1 stool every 2 to 3 days). Subjects were administered 15g of the product/day for 2 weeks. Besides macroscopic observations (stool frequency, faecal bulking, etc.), or-caecal transit time, effect on intestinal permeability, amount of faecal fat, bile acids, dry solids, etc. were monitored. There was a significant increase in stool frequency with the high performance inulin ( p=0.02). The earlier observed trend to increase faecal bulk with 1.5 to 2g per g inulin ingested was observed in present study as well. There were no effects on the other measured parameters.