Abstract
INTRODUCTIONHIGH level supplemental vitamin A has been reported to both increase and decrease the resistance of animals to carcinogenic agents. Chu and Malmgren (1965) found vitamin A to have an inhibitory effect on tumor induction by carcinogenic polycyclic hydrocarbons. McMichael (1965) reported that high levels of vitamin A inhibited the growth of Shope rabbit papillomas; and Davies (1967) observed a similar effect with vitamin A on 7,12-dimethylbenz (α) anthracene (DMBA)-induced papillomas in rhino mouse skin. Polliack and Levij (1967), however, reported an increased incidence of DMBA-induced carcinoma in the hamster cheek pouch in response to vitamin A. March and Biely (1967) observed an increased incidence of avian leukosis in laying hens fed excess vitamin A. Glavind and Arffmann (1968) cited the possible importance of zation for carcinogenic properties of lipids conjugated double bonds and trans-isomeri-using the newt test.The objective of our studies was to ascertain whether the…
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