Abstract
：Objective To study theeffect of high intensity focused ultrasound(HIFU)ablation on microvessel density(MVD)andvascular endothelial growth factor(VEGF)in rabbit hepatcocellular carcinoma(HCC)models.Methods The VX2 t umor cells were planted in the hepatic left-central lobe on30 rabbits.All animals were divided into two groups randomly:HIFU group(n=25)and controlgroup(n=5).The MVD and the expression of VEGF in the HCC was detected byimmunohistochemical SABC methods in control group and 0,1,3.7,16 d after the operation inHIFU group.Results The MVD and the expression of VEGF in the HCC tissue after HIFUtreatment in the HIFU group were decreased significantly as compared with those in thecontrol group (P＜0.01).However,there was no significant difference inMVD and the expression of VEGF in the HCC tissue after HIFU treatment in the HIFU groupamong the different time points(P＞0.05).Conclusions HIFU treatment can effectively destroythe micovessel,repress the neovascularization and reduce the blood supply of the HCC. Key words: Ultrasonography; Ultrasound,high-intensity focused; Liverneoplasms; Endothelial growth factors
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