Effect of High-intensity Interval Training Session Timing on Inflammatory Biomarkers in Overweight and Obese Individuals with Different Chronotypes

Abstract

Background: Global attention on obesity prevention emphasizes cost-effective strategies, particularly physical activity. Evaluating chronobiological influences is crucial for effective treatment plans. Noncommunicable disease management requires a nuanced approach to address this pervasive health concern. Objective: This study aims to determine the effect of chronotype-based high-intensity interval training (HIIT) on inflammatory biomarkers among overweight and obese individuals. Methods: This experimental study, involving 58 obese adults, utilized pretest and post-test evaluations. Participants, aged 31.65 ± 9.1 years with a mean BMI of 29.04 ± 4.04, underwent 12 weeks of cycling HIIT (10 sec on/10 sec off) thrice weekly. Pre- and post-training venous blood samples were collected, centrifuged, and stored at -80°C. Outcome measures included metabolic, inflammatory biomarkers, and anthropometric data. Result: The findings of this study demonstrate that there is a significant difference in metabolic variables such as fasting sugar, fasting insulin, 3.7%, 27% (p=0.00), and IL6 5.7% (p=0.00) levels between the chronotype-based exercise session group (CBES) and non chronotype based exercise session group (NCBES). Anthropometric and other inflammatory variables, such as Tumor necrosis factor alpha (TNF -alpha) and high sensitive C-reactive protein (hs CRP), showed no significant differences between groups. Conclusion: The study concluded that chronotype-based HIIT is effective on metabolic markers but not on inflammatory markers in obese individuals.