Abstract
Introduction: Accumulating evidence supports the benefits of physical activity and fitness for young people’s cognitive function. Although well-evidenced in older adults, the effects of exercise on the hippocampus in youth is relatively unknown. This study examined the impact of a 6-month school-based physical activity intervention involving high-intensity interval training (Burn 2 Learn [B2L]) on hippocampal metabolism in adolescents using magnetic resonance spectroscopy (MRS). We hypothesized that the B2L intervention would increase concentrations of N-acetylaspartate (NAA), glutamate+glutamine (Glx), total Creatine and total Choline, and decrease concentrations of Myo-inositol.
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