Abstract
Patients with high-normal or above-normal hæmatocrit were found to have impaired alertness when compared with a control group matched for age and occupation. On retesting the controls had improved alertness scores attributable to a practice effect; but the patients, when retested after reduction of hæmatocrit by venesection, had improved significantly more than the controls. Improvement in alertness correlated very well with the increase in cerebral blood flow which followed venesection. Levels of venous hæmatocrit that are generally accepted as normal may not necessarily be optimum.
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