Abstract
Experimental exposures to 8 kHz (100 dB ( SPL), 20 h) and 10 kHz (90 dB ( SPL), 20 h) were investigated using the AP of guinea pigs. About 60 naive male guinea pigs, aged 6 weeks, were used. Experimental conditions were as follows: experiment 1 control, test frequencies 9 kHz and 10 kHz; experiment 2, exposure 8 kHz 20 h, test frequencies 9 kHz and 10 kHz; experiment 3 control, test frequencies 11 kHz and 13 kHz; experiment 4, exposure 10 kHz 20 h, test frequencies 11 kHz and 13 kHz. The intensity function of the N 1 potential in the AP was measured. The N 1 potential in the AP induced by a 10 kHz tone burst was remarkably decreased after 8 kHz tone exposure. The N 1 potential of 13 kHz of the test pulse tone was remarkably decreased by 10 kHz tone exposure.
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