Effect of High Flux Versus Low Flux Hemodialysis on Some Cardiovascular Risk Factors in Egyptian Children with End Stage Renal Disease.

Abstract

Background Cardiovascular disease remains as the main cause of mortality in children with end stage renal disease (ESRD).Among the cardiovascular risk factors, dyslipidemia and inflammation are of great importance as they are both prevalent and modifiable risk factors. We aim to evaluate the effect of permeability of low-flux versus high-flux dialyzer on such 2 factors in children on regular hemodialysis (HD). Patients and Methods 48 children with ESRD were randomized into 2 groups. Group A used low-flux dialyzer, group B used high-flux dialyzer for 6 months. An initial and 6th month blood samples for lipid profile, serum albumin and serum high sensitivity CRP (hs CRP) were obtained. Statistical analysis was done. Results In the high flux group, there was a statistically significant difference in total cholesterol, HDL-cholesterol, triglyceride and hs CRP levels after 6 months when compared to baseline values of the same group, while LDL cholesterol and serum albumin showed no significant change. In the low flux group, results after 6 months didn’t show significant change in previously mentioned parameters when compared with its baseline values of the same group. Comparing these parameters between the 2 groups at 6 months, shows that high flux group has significantly lower total cholesterol, triglyceride, and hs CRP levels. Conclusion This study has demonstrated for the first time improvement of some markers of dyslipidemia and inflammation by using high-flux HD in children with ESRD. These results suggest that high-flux dialysis may benefit such young suffering population by reducing the atherogenic risk, cardiovascular morbidity and mortality.