Effect of high flux dialysis on left ventricular structure and function of maintenance hemodialysis patients

Abstract

Objectives To investigate the influence of high-flux hemodialysis (HFD) on left ventricular structure and function of maintenance hemodialysis(MHD) patients and possible mechanism.Methods 33 cases with maintenance of low-flux hemodialysis in Dalian central hospital were selected,accepted HFD 6 months of treatment.Cardiac structure and function were determined by ultrasound heartbeat graph before treatment and 6 months of HFD respectively,including left atrial diameter (LAD),left ventricular end diastolic diameter (LVDd ),left ventricular posterior wall thickness (LVPWT),interventricular septal thickness (IVST),early and late diastolic peak blood flow ratio (E / A) and isovolumic relaxation time (IRT),the corresponding calculation of ejection fraction (EF) and the calculation of left ventricular mass index (LVMI) according to Devereux and Reichek formula.Parathyroid hormone (PTH),beta 2 microglobulin (beta2-MG),advanced glycation end products (AGEs),intedeukin 6(IL-6) and high sensitivity C reactive protein (hsCRP) level were measured at the same time.Further the index of left ventricular structure and function and the clinical detection of indicators were analyzed.Results After 6 months' treatment of HFD,IRT was significantly lower (IRT118.78 + 16.06ms vs107.5 + 13.56ms,P ＜0.05),E/A were increased significantly (0.84 + 0.27 vs0.91 +0.30,P ＜0.05),LVPWT LAD,IVST,LVEF,LVMI were no statistical difference(P ＞ 0.05).And beta2-MG,AGEs,IL-6 were significantly decreased(P ＜ 0.05).Conclusions High flux hemodialysis can improve left ventricular diastolic function of patients with MHD,and its mechanism may be the effective removal of inflammatory mediators,and plasma middle molecule and macromolecule toxin. Key words: Renal Dialysis; Ventricular Function, Left