Abstract
Type 1 diabetes mellitus (T1DM) results when pancreatic β-cells are destroyed or absent, leading to decrease in insulin production and secretion. The objective of the present investigation is to screen one of the isolated fractions of Hibiscus rosa sinensis on type-1 diabetic animal model for antidiabetic activity. Experiment was conducted by dissolving basic leaf extract fraction in tween-80 (1%) with two concentrations of 100 and 200 mg/kg body weight and feed orally to Non Obese Diabetic (NOD) mice. After oral feeding of basic leaf fraction there was a significant reduction in serum glucose, glycosylated haemoglobin, triglycerides, cholesterol, blood urea in the diabetic animal model. There was enhancement in HDL and liver glycogen compared to control diabetic animal. Basic leaf fraction has demonstrated significant antidiabetic properties on type-1 animal model by enhancing insulin secretion.
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