Abstract
The actions of hexylguanidine sulfate (HG) on the cardiovascular system and blood glucose were investigated using blood pressure in spinal cat, guinea-pig heart tissue, rabbit heart and perfused ear. And the following results were obtained. In spinal cats, HG (5 mg/kg, i.v.) produces a rise in blood pressure of about 60 mmHg. The pressor actions are not affected by hexamethonium, by adrenalectomy and by pretreatment with reserpine, but are suppressed by phentolamine and by cocaine. Moreover, HG potentiates the pressor action of norepinephrine and inhibits those of tyramine, guanethidine and ephedrine. On the perfused rabbit ear, also, HG (10-5g/ml) potentiates the vasoconstriction induced by epinephrine and suppresses that induced by tyramine. However, high concentration of HG (10-4g/ml) produces vasodilation. The contractions of isolated guinea-pig atria and isolated rabbit papillary muscle are slightly decreased by HG. From the results mentioned above, it is considered that the pressor action of HG is due to a direct sympathomimetic action on the α-adrenergic receptors, but part of its action is connected with catecholamine stores in the adrenergic nerves or with some other perpheral site except the adrenal medulla. Furthermore, HG raises the blood glucose concentration of rabbit and potentiates the hyperglycaemic action by epinephrine.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
