Abstract
The acute oral toxicity (LD 50) of hexachlorophene (HCP) in the 10-day-old rat was 9 ± 2 mg/kg. After this, toxicity decreased as a function of age and the LD 50 at 32 days of age was 111 ± 12 mg/kg. In adult rats, however, the LD 50 was only about half that in a 32-day-old rat. HCP began to have a toxic effect on the brain when the rats were between the ages of 8 and 14 days. This was demonstrated by an increase in the weight and water-content of the brain, by the appearance of vacuoles in the white matter and by interference in the functioning of the central nervous system.
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