Effect of herbs on preventing diarrhea caused by irinotecan and its correlation with gene polymorphism of UGT1A1*28

Abstract

Objective: This study aimed to determine the function of herbs in preventing diarrhea after irinotecan chemotherapy and analyze the efficacy of the herbs based on UGT1A1*28 gene polymorphism. Methods: A total of 200 patients admitted to the Department of Synergistic Chinese and Western Medicine, Tianjin Medical University Cancer Institute and Hospital between October 2011 and May 2013 were randomly divided into the control (chemotherapy alone) and herb (chemotherapy combined with herbs) groups. All patients consented to UGT1A1*28 gene polymorphism detection prior to chemotherapy. Herbs were administered from 2 d prior to chemotherapy to 5 d post chemotherapy, with or without the regimen of fluorouracil, folinic acid, and irinotecan. Adverse reactions were recorded, and short-term effect was evaluated regularly. Results: A total of 144 patients had TA6/6 wild genotype, and another 56 patients had non-wild genotype (12 of the 56 cases were TA7/7 homozygous, and the other 44 cases were TA6/7 hybrid). A total of 58 patients experienced grades 2 to 4 diarrhea. A 14% decrease in the incidence of diarrhea was observed in the herb group compared with that of the control group (22% vs. 36%, P=0.029). In addition to diarrhea, grades 2 to 4 vomiting was significantly lower in the herb group than in the control group (15% vs. 27%, P=0.037). The overall response rate was 37.5%. No significant difference was found between the two groups (40% vs. 35%, P=0.465). The incidences of grades 2 to 4 diarrhea (22.9% vs. 44.6%, P=0.002) and grades 2 to 4 vomiting (23.2% vs. 16.7%, P=0.016) were lower in patients with the UGT1A1*28 wild genotype than in those with the non-wild genotype. However, in the herb group, the incidences of grades 2 to 4 diarrhea (22.2% vs. 21.9%, P=0.974) and vomiting (18.5% vs. 13.7%, P=0.777) were not significant between the non-wildand wild-type groups. Conclusion: Herbs can effectively pre作者单位:1天津医科大学肿瘤医院中西医结合科,国家肿瘤临床医学研究中心,天津市肿瘤防治重点实验室(天津市300060);2消化肿瘤内科; 3结直肠肿瘤科;4生化及分子生物学研究室 􀆽本文课题受天津市中医药管理局中医中西医结合科研项目(编号:11107)资助 通信作者:谢广茹 xieguangru@126.com 1441 中国肿瘤临床 2013年第40卷第23期 Chin J Clin Oncol 2013, Vol. 40, No. 23 www.cjco.cn vent the late diarrhea caused by irinotecan, which is also applicable in UGT1A1*28 non-wild genotype patients. Incidence of diarrhea was obviously higher in the cases with UGT1A1*28 non-wild type than in those with wild genotype. Hence, the UGT1A1*28 gene type should be detected prior to chemotherapy with irinotecan.