Effect of hepatogenous jaundice on liver stiffness measurement in patients with chronic hepatitis B

Abstract

Objective To evaluate the impact of intrahepatic cholestasis on liver stiffness measurement(LSM) of two-dimensional shear wave elastography (2D-SWE) in patients with chronic hepatitis B. Methods Between June 2011 and December 2016, total of 1 188 patients with chronic hepatitis B infection were enrolled to collect clinical, 2D-SWE, biochemical variables and histological (METAVIR scoring system) datas. LSM was compared between normal total bilirubin group(TB<23.9 μmol/L) versus abnormal TB group(≥23.9 μmol/L). Correlation of TB with LSMs was assessed. Results Nine hundred and seventy-three patients with effective LSM in the study were analyzed. Within the same fibrosis stage (F1-F4), LSM showed significantly higher value in abnormal TB group than those of normal TB group (r=0.328, 0.247, 0.495, 0.435, all P<0.001). Increased LSM for abnormal TB group was generally found within different subset of patients[fibrosis stage≤F2, ALT≥2×upper limit of normal (ULN); fibrosis stage≤F2, METAVIR activity grade ≤A1 or ≥A2], with r=0.266, 0.210, 0.243 (all P<0.001), respectively.Increased LSM for abnormal TB group was also found within different subset of patients [fibrosis stage≥F3, ALT<2×ULN, ≥2×ULN; fibrosis stage≥F3, METAVIR activity grade≥A2, with r=0.671, 0.200, 0.468 (all P<0.05)]. Conclusions Hepatogenous jaundice induced to intrahepatic cholestasis shows slight positive correlation with LSMs in patients with chronic hepatitis B. Key words: Shear wave elastography; Jaundice, hepatogenous; Hepatitis B; Elastic modulus