Abstract
Background: Liver disease caused by chronic hepatitis B virus (HBV) is emerging as a significant cause of morbidity and mortality among human immunodeficiency virus (HIV)-infected individuals.
 Methods: This study is conducted in J. L. N. Medical College & Associated groups of Hospitals patients attending from ICTC (G). 500 samples are taken randomly from January 2018 to June 2018
 Results: In the co-infected patients, ALT, AST and ALP were higher than normal. The mean serum level of ALT, AST and ALP were significantly higher in the co infected patients than in the HIV mono infected patients. The mean level of CD4+ count was significantly lower in the co infected patients than in the HIV mono infected patients.
 Conclusion: Hepatitis B virus co-infected HIV positive patients are more likely to have abnormal liver function test than the mono-infected patients.
 Keywords: HIV, Hepatitis B, CD4 count, co-infection
Highlights
human immunodeficiency virus (HIV) patients may be co-infected with other infectious organisms which are transmitted through common modes of transmission
The mean level of CD4+ count was significantly lower in the co infected patients than in the HIV mono infected patients
In the Middle East and Indian subcontinent an estimated 2–5% of the general population is chronically infected with hepatitis B virus (HBV). [Approximately 10% of the HIV-infected population worldwide suffers from chronic hepatitis B] Coinfection rates of HBV in HIV patients vary worldwide and largely depend upon the geographical location, risk groups, the type of exposure involved and the socioeconomic condition of that particular region
Summary
HIV patients may be co-infected with other infectious organisms which are transmitted through common modes of transmission. Patient may be co-infected with HBV, through common modes of transmission. Liver disease caused by chronic hepatitis B virus (HBV) is emerging as a significant cause of morbidity and mortality among human immunodeficiency virus (HIV)-infected individuals. [Approximately 10% of the HIV-infected population worldwide suffers from chronic hepatitis B] Coinfection rates of HBV in HIV patients vary worldwide and largely depend upon the geographical location, risk groups, the type of exposure involved and the socioeconomic condition of that particular region. Though the mortality and morbidity rate from HIV/Acquired Immunodeficiency Syndrome (AIDS) have declined as a result of highly active antiretroviral therapy (HAART), liver disease due to chronic HBV infection has become a leading cause of death. There is paucity of data regarding correlation of liver enzymes and CD4 T-cells among HIV/HBV co-infected patients. Risk of progression to severe liver diseases with higher susceptibility towards hepato-toxicity due to antiretroviral therapy.[3]
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