Abstract
Hypophysectomized dogs were used to study the effect of hemorrhage-induced hypotension upon the responsiveness of the adrenal cortex to adrenocorticotrophin (ACTH). Adrenal venous blood samples were collected under sodium pentobarbital anesthesia and were analyzed for 17-hydroxycorticosteroids (17-OHCS). ACTH was infused intravenously throughout each experiment. A sustained rise in adrenal 17-OHCS secretion was produced. Marked falls in arterial blood pressure and adrenal blood flow were induced by a removal of 20-25ml/kg of arterial blood. The rate of adrenal 17-OHCS secretion was decreased to the level of 28-65% of the pre-hemorrhage secretion rate.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
