Effect of Hemodialysis on Serum Copper and Zinc Levels in Renal Failure Patients

Nitin G Joshi,Adinath N Suryakar,Rajashri B Bhogade

doi:10.29333/ejgm/82248

Abstract

For human beings trace elements are essential nutrients with a gamut of functions. Available data regarding trace element status in hemodialysis patients are contradictory. The present study was aimed to investigate possible existence of trace element disturbances in uremic patients undergoing dialysis treatment. Blood samples of forty hemodialysis patients and twenty healthy controls were analyzed for quantitation of copper and zinc. The study revealed that serum copper and zinc concentrations in hemodialysis patients are distinctly decreased compared to that of healthy controls. Abnormalities of trace elements are primarily the result of uremia, and they may be further exacerbated by the dialysis procedure.

Highlights

Uremia is characterized by functional and biochemical disturbance that result primarily from the diseased kidney’s diminished capacity to remove organic solutes from the body
Substances present in dialysate but not in blood will tend to accumulate in the patient, and the lack of renal clearance in hemodialysis patients might theoretically lead to toxicity of ingested trace elements even when they are not present in dialysate
Hemodialysis patients are at theoretical risk for both deficiency and accumulation of trace elements, depending on dietary intake, removal by dialysis, the composition of the source water used for hemodialysis, and residual kidney function [2,3,4]

Summary

INTRODUCTION

Uremia is characterized by functional and biochemical disturbance that result primarily from the diseased kidney’s diminished capacity to remove organic solutes from the body. Received: 03.03.2012, Accepted: 11.03.2013 concentrations in dialysate than in blood tend to be removed by dialysis. This is appropriate in the case of uremic toxins, it may lead to depletion of biologically essential substances. Substances present in dialysate but not in blood will tend to accumulate in the patient, and the lack of renal clearance in hemodialysis patients might theoretically lead to toxicity of ingested trace elements even when they are not present in dialysate. Hemodialysis patients are at theoretical risk for both deficiency and accumulation of trace elements, depending on dietary intake, removal by dialysis, the composition of the source water used for hemodialysis, and residual kidney function [2,3,4]. Student’s ‘t’ test was done for comparison of data

MATERIALS AND METHODS

RESULTS

DISCUSSION