Effect of hemodiafiltration on renal function in elderly patients with uremia

Abstract

Objective To investigate the effect of hemodiafiltration (HDF) on renal function in elderly patients with uremia. Methods From February 2015 to February 2017, 94 cases of elderly patients with uremia in our hospital were selected, among them, 45 cases were treated with HDF (HDF group), and 49 cases were received conventional hemodialysis (HD) (HD group), the levels of toxin and residual renal function were observed before and after dialysis in the two groups. Results Homocysteine (Hcy), parathyroid hormone (iPTH), urea nitrogen (BUN) and creatinine (Scr) of HDF group after dialysis 1 month were lower than pre dialysis (P<0.05). Hcy, BUN and Scr of HD group after dialysis 1 month were lower than pre-dialysis (P<0.05). Hcy, and iPTH of HDF group after dialysis 1 month were (24.08±4.52) mol/L and (1.63±0.70) g/L, significantly lower than that of HD group (P<0.05). After dialysis 1 month, residual renal urea clearance (KRU) of HDF group was (1.22±0.30) mL/min, significantly higher than the HD group (P<0.05). The complication rate of HDF group was 2.22%(1/45), which was significantly lower than that of HD group (P<0.05). Conclusions Compared with HD treatment, HDF can effectively remove the harmful substances in serum, and has little influence on the residual renal function of patients, less complications, it is worthy of clinical application. Key words: Uremia; Hemodiafiltration; Aged