Effect of heme oxygenase–endogenous carbon monoxide on mortality during septic shock in rats

Abstract

AimTo investigate the effect of HO–CO on mortality during septic shock in rats.MethodEighty rats were randomly divided into group-control, group ZnPP-IX, group SS, and group LZ.ResultsDeath was significantly lower in group SS than in group LZ (P < 0.05). The MAP was significantly higher in the group LZ than in the group SS (P < 0.05). ALT, AST, Cr and BUN, MDA, and the lung EB contents, were significantly lower in the group SS than that in the group LZ (all P < 0.05). And CO and SOD activities were significantly higher in group SS than that in the group LZ (all P < 0.05). HO-1 mRNA, and HO-1 protein were significantly lower in the group LZ than in the group SS (P < 0.05), whereas HO-2 mRNA, and HO-2 protein were not significantly different among four groups (all P > 0.05).ConclusionThe increased oxidative stress and end-organ damage is related to mortality during septic shock; while the hypotension partly contributing to HO-1 protein and CO has no obvious relation with it.