Effect of hematocrit levels on cardiac function and structure in hemodialysis patients

Abstract

Objective The effect of hematocrit levels on cardiac function and structure in hemodialysis patients will be investigated,providing some clues for the clinical goals enacting in renal anemia patients.Methods About 69 hospitalized uremia patients receiving regular hemodialysis treatment at least 6 months between January 2011 and June 2012 in the hemodialysis center of Zaozhuang Municipal Hospital were collected in the study.The effect of hematocrit levels on cardiac function and structure in hemodialysis patients was inspected.The 69 uremia patients were divided into 5 groups according to the levels of HCT:group A (10％≤HCT＜ 20％) 9 cases,group B (20％≤HCT＜25％) 18 cases,group C (25％ ≤HCT ＜30％) 21 cases,group D (30％ ≤HCT＜ 33％) 14 cases,and group E (HCT≥33％) 7 cases.The difference in cardiac function indexes among the 5 groups was determined by Randomized Block Design Analysis of Variance (ANOVA),and the HCT related changing trends were also investigated.Results As the HCT rises,levels of LVEF were grown up accordingly,group A to group E was (47.7 ± 6.5)％,(55.8±1.3)％,(51.5± 12.7)％,(56.7±9.5)％ and(68.5 ± 4.0)％,respectively; LVEF of group E was higher than group D.LVESD of group A to group E was (38.0 ± 7.3),(32.4 ± 5.9),(41.8 ± 9.9),(39.3 ± 7.7) and (33.2 ± 1.0)mm,respectively; statistical significance was found between group B and group C(P ＜ 0.05).Conclusions The higher levels of HCT (≥ 33 ％) and long-term maintenance may significantly improve the left ventricular systolic function and reduce the chances of heart failure in hemodialysis patients.It also has the trend to reverse the left ventricular hypertrophy. Key words: Renal dialysis; Kidney failure,chronic; Hematocrit; Heart failure