Effect of Helicobacter pylori Infection on Haematological Parameters in Kosti Teaching Hospital, Sudan

Abstract

Background: Helicobacter pylori infection is a major global gastric infection and has been associated with changes in haematological parameters. Objectives: The present study aimed at establishing the effect of H. pylori infection on haematological parameters. Methods: We conducted a case-control study among 98 patients and 62 controls in Kosti teaching hospital in Sudan from July 2014 to July 2015. All patients and controls were investigated for complete blood count, peripheral blood picture, and Helicobacter pylori infection. Data were analysed using SPSS Version 23 at 95% confident interval. Results: There was a significant effect of H. Pylori infection on all haematological parameters (p ≤ 0.001), except for MCHC, WBCs, and total differential (p ≥ 0.001), at the rate of 89.80%, infection was recorded in patients with gastritis. However, after one month follow- up, the Hb, PCV, MCV Retic, and platelet count for GIa were found to be not significant (p ≥ 0.001) for all; 12.11 ± 1.11 g/dL, 40.33 ± 3.09 %, 81.36 ± 3.5 fL and 1.38 ± 0.84 %, 233700.0000 ± 34947.7400 cmm3, respectively. On the other hand, GIb, Hb, PCV, MCV, Retic and platelet counts were reported to be significant (p ≤ 0.001), for all; 10.33 ± 1.82 g/dL, 33.99 ± 3.48%, 111.01 ± 7.89 fL, 3.20 ± 1.24 % and 112895.6000 ± 41043.0500 cmm3. In the GII, all were found to be significant (p < 0.001), 8.58 ± 1.93 g/dL, 30.86 ± 3.10 %, 60.13 ± 4.44 fL 4.53 ± 1.84%, 317818.2000 ± 91442.7600 cmm3, except for the retic and platelet count (p ≥ 0.001). Conclusions: There was a significant effect of H. pylori infection on haematological parameters. The complete blood count and peripheral blood picture revealed that group Ia, group Ib, and group II were normocytic anemia, macrocytic anemia, and microcytic anemia, respectively.