Effect of heavy exercise and forced running training on serum lipid peroxide

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The purpose of this present study was to evaluate the effect of heavy exercise (triathlon) on man (Exp. I) and moderate running training in rat (Exp. II) on serum lipid peroxide (SLPO). Subjects in Exp. I were 7 triathletes aged 27 to 39 yrs. Blood samplings were taken before race and immediately after completion of each sports activity. In Exp.II, SLPO was divided into 2 components, i.e., aspirin-inhibiting SLPO and other (non-specific SLPO). Wistar male rats (n= 50) 6 wks of age, were divided into 2 groups, i.e., control (n=25) and training (n=25) groups. Moderate running training was performed on treadmill for 6 wks. At 12 wks of age, exhaustive running (ER) test was performed. Blood samples were collected at rest and immediately after ER in both groups. The results of the present study were as follows : l) SLPO during triathlon race was gradually decreased, but not significant. 2) Although total SLPO at rest in trained rats was significantly increased as compared with control, non-specific SLPO at rest in both groups was not significant. 3) Total SLPO in trained rats was significantly higher than that of control after ER. Total SLPO after ER in both groups was not significantly increased as compared with resting level. 4) Non-specific SLPO after ER in both groups was not significantly different between 2 groups. 5) Non-specific SLPO after ER in both groups was significantly increased as compared with resting level. Increasing rate in control and training rats were 121% and 73%, respectively. 6) Although significant correlation was not observed between total SLPO and blood lactate, a good correlation was found between non-specific SLPO and blood lactate.