Abstract
High temperatures lead to oxidative stress. The aim of the study was to determine whether heat stimulation-induced hyperthermia can increase the level of circulating irisin. Twenty-one healthy female subjects (age, 26.3 ± 2.71 years; height, 162.1 ± 3.15 cm; weight, 54.2 ± 3.86 kg; and body surface area, 1.57 ± 0.11 m2) not taking contraceptives participated in this study. All experiments were performed individually for each participant when they were in the early proliferative menstrual phase. In an automated climate chamber (25 ± 0.5°C), the heat load was applied via half-body immersion into a hot water bath (42 ± 0.5°C). Five-minutes break was provided every after 5 min of immersion and the total passive heating time was 30 min. Tympanic temperature (Tty) and skin temperature (Ts) were measured. Mean body temperature (mTb) was calculated. Blood samples were collected before and immediately after immersion. Levels of irisin, cortisol, creatine kinase (CK), and lactate dehydrogenase (LDH) were analyzed. Tty, mTb and serum irisin levels increased after hot water immersion. The blood levels of cortisol, CK, and LDH were also elevated after hot water immersion. Heat stimulation might increase the levels of circulating irisin in humans in response to oxidative stress.
Highlights
Irisin is a newly discovered myokine: proteolytic fibronectin type III domain containing 5 (FNDC5)-cleaved product
The aim of the present study is to evaluate whether heat stimulation-induced hyperthermia can increase circulating irisin levels after half-body immersion in hot water
Irisin levels were elevated after hot water immersion from 7.43 ± 1.88 to 9.00 ± 2.34 ng/mL (P < 0.001) (Figure 2)
Summary
Irisin is a newly discovered myokine: proteolytic fibronectin type III domain containing 5 (FNDC5)-cleaved product. Circulating levels of irisin increase transiently during acute exercise, and irisin concentrations are positively correlated with the intensity of exercise (Bostrom et al, 2012; Huh et al, 2014a; Huh and Mantzoros, 2015). Such an effect was less pronounced in previous studies. Irisin has been shown to increase temporarily after exercise, but not sustained in the long term (Huh et al, 2014b; Kraemer et al, 2014; Singhal et al, 2014)
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