Abstract
Objective: To explore the therapeutic effect and mechanism of Gynostemma Pentaphyllum (GSM) on spleen-qi deficiency mice. Method: Mice were randomly divided into 4 groups: normal group, model group, Sijunzi decoction, Gynostemma Pentaphyllum group. The mice were given rhubarb decoction at the concentration of 1.56 g/kg by gavage for 5 days to establish spleen-qi deficiency mice model. The basic characteristics of weight, rectal temperature, stool, appetite and other characteristics of mice were observed. Swimming time, Water Maze Experiment, Open Field Test and serum immunoglobulin were detected. Result: Compared with model group, Gynostemma Pentaphyllum can significantly improve body weight of mice. Compared with model group, the swimming time of Gynostemma Pentaphyllum group was significantly increased on the fourth day, the vertical movement time and the number of swimming cycles, as well as the concentration of immunoglobulin IgG in the Gynostemma Pentaphyllum group was increased. Conclusion: Gynostemma Pentaphyllum has a certain effect on the overall treatment of spleen-qi deficiency mice. The therapeutic effect of Gynostemma Pentaphyllum on spleen-qi deficiency mice may be related to increase the immunoglobulin levels.
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