Abstract
Gastric inhibitory polypeptide (GIP), pancreatic polypeptide (PP), glucagon, vasoactive intestinal polypeptide (VIP), bombesin, neurotensin, substance P, and cholecystokinin octapeptide (CCK-OP) were examined for their effects upon glucose-stimulated insulin secretion in denervated and isolated islet cells, namely, monolayer cultures of dispersed neonatal rat pancreatic islet cells. Only glucagon (14 nM), GIP (10 and 20 nM), and CCK-OP (20 nM) enhanced glucose-stimulated insulin release during a 60-min incubation period. None of the others altered insulin secretion under the conditions employed, although reported to influence insulin release in other systems.
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Schedule a callMore From: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
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