Effect of guar gum-based carriers on the physical and bioactive properties of spray-dried delivery systems of ground ivy (Glechoma hederacea L.)

Abstract

The aim of the present study was to develop, for the first time, highly efficient spray-dried encapsulation systems of ground ivy (Glechoma hederacea L.) polyphenols using partially hydrolyzed guar gum (PHGG) and its binary systems with collagen hydrolyzates, carboxymethyl cellulose, nutriose, mucin and xylan. All carriers were subjected to differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) to estimate their thermal behavior and stability. In the formulated spray-dried particles, the influence of different carriers on their physical-chemical (wettability, bulk density, zeta potential, morphology, size and FT-IR spectroscopy) and bioactive (encapsulation yield and simulated gastrointestinal digestion) properties were determined. The addition of each of the polymers used to the PHGG system increased the process yield and affected most of the physical parameters, with the exception of the diameter of the particles. The highest encapsulation yield (94.64%) for the most dominant phenolic compound - rosmarinic acid, was observed for particles made of PHGG and mucin, while PHGG-carboxymethyl cellulose particles showed controlled and continuous release in simulated gastrointestinal digestion, that can be associated with the highest values for wettability (2553.5 s) and water contact angle (87°).