Abstract
BackgroundAcute myocardial infarction (AMI) is the most serious and lethal manifestation of coronary heart disease worldwide, presenting extremely high disability and mortality. Our previous studies have shown that Guanxin V (GXV) could significantly improve the cardiac function and the blood flow dynamics, and reduce serum levels of inflammatory factors in AMI rats, thus triggering ventricular remodeling (VR) at post-AMI.MethodsAn in vivo AMI model was established in Syrian hamsters by performing the ligation of the left anterior descending coronary artery. Syrian hamsters were randomly divided into four groups, namely Sham operation group (n = 12), AMI group (n = 12), GXV group (GXV 6 g/Kg/d, n = 12), and Tranilast group (Tra 105 mg/Kg/d, n = 12). Drug intervention was conducted for consecutive 8 weeks. Relative biological indicators were measured in the 4th and 8th week, respectively.ResultsCardiac functions were improved, and the infarcted size and heart weight index were limited in Syrian hamsters of GXV and Tra groups compared with those in AMI group. Furthermore, GXV was able to decrease the number of mast cells and chymase level in Syrian hamsters with AMI. Administration of GXV remarkably inactivated the renin-angiotension-aldosterone system, and alleviated myocardial fibrosis and cardiomyocyte apoptosis, thus slowing down VR at post-AMI.ConclusionGXV slows down the process of VR at post-AMI by reducing chymase level and mast cells number, as well as inactivating the reninangiotension-aldosterone system..
Highlights
Acute myocardial infarction (AMI) is the most serious and lethal manifestation of coronary heart disease worldwide, presenting extremely high disability and mortality
ultra-performance liquid chromatography (UPLC) profile and constituent contents of Guanxin V (GXV) The main components of medicated sera of GXV were analyzed by comparing with the second-order chromatogram and serum pharmacochemistry method
GXV effectively improved cardiac function in AMI hamsters ejection fraction (EF) and fractional shortening (FS) were significantly enhanced after treatment of GXV and Tranilast for 8 weeks compared with those of AMI group (EF: 61.94 ± 3.76% in GXV group and 59.98 ± 4.683% in Tra group v.s. 37.82 ± 4.73% in AMI group; FS: 37.07 ± 3.90% in GXV group and 33.03 ± 9.08% in Tra group v.s.20.50 ± 3.68% in AMI group)
Summary
Acute myocardial infarction (AMI) is the most serious and lethal manifestation of coronary heart disease worldwide, presenting extremely high disability and mortality. Acute myocardial infarction (AMI) is a severe and lethal coronary heart disease with extremely high disability and mortality [1]. Guanxin V (GXV) is produced by the Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine (Nanjing, China) It is applied for the treatment of coronary heart disease, myocardial. Crude terpene glycoside components in Red Peonies is capable of protecting myocardial ischemia by stimulating cardiac energy metabolism and inhibiting myocardial apoptosis via activating the PI3K/AKT/mTOR signaling pathway [10]. Schizandra Berry and its main components protect against cardiovascular diseases mainly through suppressing oxidative stress, cardiomyocyte apoptosis and inflammatory response [11]. It is believed that GXV, a traditional Chinese medicine can be applied in the treatment of heart diseases
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