Effect of Growth Hormone Therapy in Children with Isolated Growth Hormone Deficiency

Abstract

The most frequent reason of short stature is Idiopathic short stature (ISS). If this condition is left untreated, the person's final height will be below the normal height range. Objective: To determine the efficacy of growth hormone treatment in short-stature children with isolated growth hormone deficiency. Methods: This was a retrospective cross-sectional study conducted in the department of Pediatric Endocrinology, Children Hospital, PIMS after approval from ethical review board. Epidemiological characteristics and response to therapies were noted and frequencies and Means were calculated. SPSS version 22 was used for statistical analysis. Results: Out of 87 study participants, there were 47 males and 40 female patients. The mean age was 10.04 + 1.89. The mean height and weight of study participants was 105.13 + 16.98cm and 21.55 + 7.63kg respectively. The mean isolated growth hormone value was noted as 5.40 + 1.43. The majority of the study participants were consanguineous i.e., 77%. Almost 48.3% study participants had growth hormone deficiency. The mean growth hormone velocity at 6th and 12th month was 6.52 + 2.08 and 7.89 + 2.54 respectively. In the end majority of the participants (82.8%) showed improvement. At 6th and 12th month both time points the results depicts a statistically significant difference among both groups (Improved Vs. Consistent) (p-value < 0.001). Conclusions: Recombinant growth hormone (GH) is an effective treatment for patients with GH deficiency to improve their growth. It was concluded that the children with ISS showed improvement after receiving GH therapy.