Abstract
Bovine growth hormone ( GH) was administered at 1 mg/kg day for various periods of time to normal dogs. The effects produced on plasma free fatty acid ( FFA) metabolism were studied in these animals, in the unanesthetized state, using palmitate-C14. At 3–9 hr following intravenous injection of growth hormone significant increase were observed in plasma FFA concentration, turnover rate, total amount of FFA oxidized to CO2, and per cent of total respiratory CO2 derived from FFA. FFA production was increased by GH; FFA uptake and oxidation increased in parallel with plasma FFA concentration and apparently were not affected directly by GH. Similar changes were observed after 2 days of GH. After 7 days of GH all these parameters returned to control values. The transient effect of GH on FFA metabolism is in contrast with its reported prolonged effects on fat metabolism; possible reasons for this discrepancy are discussed.
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