Abstract
Bovine growth hormone was administered to hypophysectomized female C3H mice at increasing dose levels to maintain continuous growth. Within a period of 25 weeks the initial weight of the animals had doubled. Plateauing was observed at all dose levels, but it was found that gains could always be reinitiated by increasing the dose level. It was also demonstrated that although thyroxine was ineffective as an independent growth factor, when administered at a daily dose level of 0.0003 mg. together with growth hormone for longer than 8 weeks, it did act as a synergist with the latter in effecting body weight increases. When thyroxine in increasing dose levels was administered together with growth hormone, toxic effects were observed. 0.003 mg. of thyroxine plus growth hormone produced enlarged adrenal glands in all the mice so treated; from histological sectionsof the gland it was apparent that the enlargement could be attributed primarily to the extensive development of one region of the adrenal cortex, the j...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
