Abstract
Our recent study demonstrated a bone‐protective role of green tea polyphenols (GTPs), extracted from green tea, in estrogen‐deficiency‐induced bone loss of middle‐aged female rats through an increase of antioxidant capacity and/or a decrease of oxidative stress damage. This study further examines effects of GTPs on chronic‐inflammation‐induced bone loss of female rats. A 2 (placebo vs. lipopolysaccharide, LPS) × 2 (no GTPs vs. 0.5% GTPs in drinking water) factorial design using 40 female rats (3‐month‐old) assigned to 4 groups (n=10/group): placebo (P, placebo implantation), LPS implantation (L), P+0.5% GTP (PG), and LPS+0.5% GTP (LG) for 12 wks. After 12 weeks, LPS resulted in a significant increase in inflammation index based on white blood cell count (WBC), accompanied by a significant decrease in bone mineral density (BMD). Supplementation of GTP significantly lowered the WBC and increased BMD. Neither LPS nor GTP affected cortical bone parameters measured by microcomputed tomography at femur midshaft. These results demonstrated that GTPs supplementation mitigates LPS‐induced bone mineral density loss in female rats. Such a protective role of GTPs may be, in part, attributed to decreased inflammation. This study suggests a potentially significant prophylactic role of green tea in bone health of women with chronic inflammation‐induced bone loss.
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