Abstract

Evidence for benefits of anti-oxidative power of polyphenols in cardiovascular diseases has been established. In the present study, effect of polyphenol rich green tea on selected metabolic biomarkers among Asian Indian women with metabolic syndrome in normal free living condition has been recorded. Thirty three Asian Indian women (>30 y) confirmed as having metabolic syndrome, were enrolled for the present study based on written informed consent. Subjects were asked to consume three cups of green tea daily for a period of four months. Regular telephonic contact and periodic visit to supply the tea were made to ensure compliance with the intervention and maintenance of lifestyle and dietary pattern, as followed before the experimental period. Parameters analyzed at baseline have been used as control data to eliminate individual variation. Double-blind analysis of selected metabolic markers was done at baseline, 2 months and 4 months of the intervention period. At four months, a significant reduction from baseline was observed in weight (2%), waist circumference (4.5%), blood sugar (4%), glycosylated hemoglobin (4%), total cholesterol (11%) and LDL cholesterol (13%) (p < 0.01). The effect of green tea consumption on BMI, fasting insulin, HDL cholesterol, triglyceride, VLDL, C-reactive protein and homocysteine levels was either inconsistent or non significant. The present study showed that green tea consumption by free living subjects with metabolic syndrome resulted in significant improvements in some of the cardiovascular risk factors including visceral fat, blood sugar and cholesterol level.

Highlights

  • There is strong evidence to suggest beneficial effects of dietary polyphenols in reducing several oxidative stress related health problems including cardiovascular mortality rate [1]

  • The present study aims to determine the effect of green tea supplementation on metabolic biomarkers among the metabolic syndrome patients

  • Regular consumption of 3 cups of green tea per day by the subjects resulted in significant differences in the Metabolic syndrome (MS) biomarkers

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Summary

Introduction

There is strong evidence to suggest beneficial effects of dietary polyphenols in reducing several oxidative stress related health problems including cardiovascular mortality rate [1]. A group of polyphenols, present in green tea, have been found to exhibit anti-oxidant properties. Anti-obesity effects of green tea catechins in terms of increased energy expenditure, increased fat oxidation, decreased appetite, and decreased GI absorption have been reported by Rains, Agarwal & Maki (2011) [3]. Metabolic syndrome (MS) is characterized by presence of several risk factors such as diabetes and prediabetes, abdominal obesity, high cholesterol and high blood pressure [7]. These parameters may be positively affected by supplementation with green tea polyphenols. The present study aims to determine the effect of green tea supplementation on metabolic biomarkers among the metabolic syndrome patients

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