Abstract
Some interventions, such as coffee powder, are applied on wound to facilitate healing process. Coffee has several properties that can facilitate wound healing. Application of Robusta coffee bean ointment 22.5 % on full thickness wound could increase fibroblast. Povidone iodine 10% has remained popular as wound antiseptic. This study aimed to evaluate the effect of green coffee bean extract in lower concentration for healing wound in rats. This study used male Sprague Dawley rats, 10 rats in each group. The skin incision was held in right back of rats with a diameter of 1.5 cm under lidocaine anesthetic subcutaneously. Group I was not given intervention, group II was given liquid povidone iodine 10%, and group III was given 15% green coffee bean extract in vaseline base. Interventions were held every day without wound debridement. Wound size was measured at day 0, 7 and 16. Animals were sacrificed at day 7 (proliferative phase) and 16 (remodeling phase). Sections were stained using Haematoxilyn-eosin. Histopathology assessment of wound tissue is on reepithelization and presence of: inflammatory cells, fibroblast, collagen, and vascularization. Green coffee extract could increase wound contraction and accelerated wound healing. Histopathology result on day 7 showed that green coffee extract had high response inflammatory cells and fibroblast. The provision of 15% green coffee bean extract ointment can accelerate wound healing with higher inflammation response and fibroblast in proliferative phase .
Highlights
Roasting coffee beans powder has been used as traditional medicine in wounds healing
The wound healing effect of 15% ointment of green coffee extracts in wound contraction and complete healing is shown in Table 1 and Figure 1
Wound contraction in group of green coffee extract were highest among the others, followed by no treatment group and povidone iodine group
Summary
Roasting coffee beans powder has been used as traditional medicine in wounds healing. Many local health provides reported coffee powder sprinkled on wound does not cause infection [1]. Experimental study with rats has showed result that roasted coffee beans extract ointment base dose 22,5 % could increase inflammatory cells, fibroblast, and blood vessels in wound area on day 4 [2]. The chemical constituent of coffee include phenolic compounds and their derivatives (such as chlorogenic acids), alkaloid (especially caffeine), diterpenoid alcohols (such as cafestol and kahweol) [3]. Chlorogenic acids has been shown to accelerate the skin wound healing and burn healing [1,3]. There are a different chlorogenic acids amount in green coffee and roasted coffee, green coffee has higher amount of chlorogenic acids than roasting coffee beans [3]
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