Effect of Grape Seed Procyanidins Extract on Lipolysis in Rats

Abstract

The objective of this study was to investigate the effects of grape seed procyanidins extract (GSPE) on lipolysis in rats. Body weight, serum lip level, glucose tolerance, insulin tolerance and gene expression level of FAS, ACC1, Cpt1a and HSL in liver of standard diet (SD) or high fat diet (HFD) treated rats by gavage were measured. The results showed that 150 mg kg-1 d-1 of GSPE is effective in decreasing body weight, serum lip level and blood glucose value of SD and HFD treated rats compared to control. Meanwhile, GSPE can improve the trend of high blood glucose and insulin resistance in obese rats and show the dose-independent manner. Furthermore, application of 150 mg kg-1d-1 GSPE was found to be most effective in suppressing FAS and ACC1 genes expression levels and increasing Cpt1a and HSL genes expression levels in liver of SD (P<0.05) and HFD (P<0.01) treated rats compared with the control treatment. Based on these results, we concluded that GSPE can inhibit the lipid deposition of HFD treated rats, furthermore, it can also influence the gene expression levels of related with lipid metabolism and the glucose-tolerance and insulin-tolerance to co-regulate the lipid metabolism in obese rats.