Abstract

Effect of Grape Seed Oil on Hepatic Function in Adult Male Rabbits Treated with Sodium Fluoride (Part-II)

Highlights

  • Fluoride is an essential trace element widely distributed in the nature

  • This study was designed to investigate the beneficial effect of natural antioxidant against deleterious effect of sodium fluoride in drinking water in adult male rats

  • Serum samples were used for measurements:Glutathione concentration (GSH) according to (Burtis and Ashood, 1999), total serum protein concentration using total serum protein kit –Linear chemicals, Barcelona, Spain), blood glucose concentration, serum aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities using blood glucose kit, ALT and AST kit (BioMeriux, Spain)

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Summary

INTRODUCTION

Fluoride is an essential trace element widely distributed in the nature. Fluoride can occur naturally in surface waters as a result of the deposition of particulates from the atmosphere and the weathering of fluoride-containing rocks and soils. Ground water can contain high concentrations of fluoride owing to leaching from rocks. Natural geological sources and increased industriazation and attendants environmental pollution have contributed greatly to the increasing evidence of fluoride-related human health issue. High levels of fluoride in drinking water have been a potential hazard all over the world (Susheela, 2007; Susheela et al, 2013). Besides its hyperlipidemic effect (Khudair and Aldabaj, 2014), metabolic, functional and structural damages caused by chronic fluorosis have been reported in many tissues, including kidney This study was designed to investigate the beneficial effect of natural antioxidant against deleterious effect of sodium fluoride in drinking water in adult male rats

MATERIALS AND METHODS
RESULTS AND DISCUSSION
CONCLUSION
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