Abstract
ObjectivesTo investigate the effect of grape juice ingestion in the inflammatory process in overweight and insulin resistance women. MethodsAn intervention study was conducted, in which, for 4 weeks, the volunteers ingested 500 mL of grape juice daily. Blood samples were collected at baseline and 2 and 4 weeks after the beginning of the grape juice ingestion. The study population consisted of healthy women (n = 20), aged between 18 and 40 years, and body mass index classified as overweight (25–29.9 kg/m2). Lipid profile and plasma glucose, insulin, leptin, adiponectin, inflammatory biomarkers (IL-10, IL-6, TNF-α, C-reactive protein, MCP-1, VCAM-1, and ICAM-1) levels were analyzed. Food consumption was evaluated by the analysis of three 24 hours recalls collected at all times. ResultsThe intake of grape juice promoted a significant increased (P < 0.05) in plasma triacylglycerols levels after 4 weeks of ingestion in comparison to the baseline. The intervention with grape juice significantly reduced plasma sICAM-1 levels after 4 weeks in comparison to the baseline. ConclusionsGrape juice reduced a biomarker related to endothelial dysfunction in overweight and insulin resistance women. Funding SourcesFood Research Center (FoRC), Sao Paulo Research Foundation (FAPESP).
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