Effect of grape consumption on metabolic parameters in obese adults (831.11)

Abstract

Consumption of polyphenol‐rich grapes has previously shown cardioprotective effects. This randomized, double‐blind, crossover study aimed to determine the impact of whole grapes on biomarkers of cardiovascular disease risk compared to placebo. We examined plasma lipids, glucose, insulin, and C‐reactive protein in obese adults (mean BMI 39.2 ± 11.7) in good health. Diets included 60 g of whole grape powder (WGP), equivalent to 2 cups whole grapes providing 300 mg total polyphenols, or placebo(C) matched in calories and appearance providing 0 mg polyphenols. Subjects completed two 4‐wk intervention periods, separated by a 2‐wk washout, during which they consumed WGP or C once daily in addition to low polyphenol diets. Fasting blood samples were drawn at beginning and end of each intervention period. Acute postprandial effects at 1, 3, and 5 h were examined following consumption of WGP or C with a standardized high fat, high carbohydrate test meal. Preliminary data reveals subjects receiving WGP had no significant differences in fasting metabolic parameters compared to C, with exception of HDL (p<0.05). Similarly, postprandial AUC for glucose, insulin, and TG did not differ. Further evaluation is needed to determine if grape consumption improves other metabolic biomarkers in the obese population.Grant Funding Source: Supported by CTGC and USDA CRIS CA‐S*‐NTR‐6316‐H