Effect of Granulating Method on Particle Size Distribution of Granules and Disintegrated Tablets. I

Abstract

AbstractThe average particle size and distribution of granules were found to be dependent on the granulating method. The slugging method produced the widest particle size distribution and the largest average particle size, while the microgranulating method produced the narrowest distribution and the smallest average particle size. The average particle size of dexamethasone granules produced by wet granulating, microgranulating and slugging methods, were reduced on compaction by fragmentation. Of the three, the granules prepared by the slugging method, exhibited maximal average size reduction on compaction. On the other hand, the average particle size of sulfadiazine microgranulates and sulfadiazine slugs were enlarged by consolidation during compaction.