Abstract
Kidney insulin-like growth factor-I (IGF-I) increases transiently following unilateral nephrectomy, thus preceding the compensatory renal growth. The aim of the present study was to investigate the effect of different degrees ( 1 7 to 2 3 ) of renal ablation on kidney and serum IGF-I and IGF binding proteins (IGFBPs) during a 7-day study period. All nephrectomized rats exhibited an increase in the weight of the remaining renal tissue. Kidney IGF-I measured in kidney pieces close to and away from the resected area increased transiently and more significantly away from the resected area, with significant correlation to the amount of tissue resected (day 1, r = .73, P < .0001; day 2, r = .49, P < .05; and day 7, r = .48, P < .05). No changes in kidney IGFBPs or serum IGF-I were observed. Serum IGFBP-4 correlated to the degree of renal resection, as did changes in serum urea and creatinine. In conclusion, significant correlations were observed between local changesin kidney IGF-I and serum IGFBP-4 levels and the degree of renal ablation, suggesting a role for IGF-I as a renotropic factor and, further, that IGFBP-4 is removed to a major extent through the kidney.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
