Abstract
Introduction: Currently, the potential application of gold nanoparticles (AuNPs) to increase the efficiency of radiation therapy have been investigated. However, the loss of an appropriate method to estimate the dose distribution in nanoparticle laden tissue limits the applicability of nanoparticles in radiotherapy clinics. Polymer gel dosimetry provides an accurate and precise system that enables to measure the dose distribution in full three dimension. In this study, the radiation dose enhancement effect of AuNPs was assessed through gel dosimetry analysis. Materials and Methods: To achieve the mentioned goal, AuNPs were impegrated in MAGIC_f polymer gel dosimeter and irradiated by 6Mv X-ray beam. Irradiated gel was then evaluated by two modalities of Magnetic Resonance Imaging (MRI) and Optical Computed Tomography (OCT). Results: MRI and OCT scanning of the MAGIC_f geles containing 0.1 mM AuNPs demonstrated dose enhancements of 7.8% and 6.8%, respectively. Conclusion: Polymer gel dosimetry has the potential to provide a new platform for investigation and optimization of the applicability of nanoparticles in radiation therapy
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
