Effect of Gold Nanoparticles Contrast Agent Concentration on X-Ray Diagnoses: Experimental and Computational Study

Abstract

Nanotechnology applied to biological problems represents an emerging filed with its potential to offer extremely sensitive diagnostics and targeted cancer therapies. Gold nanoparticles (GNPs) are of interest as potential in vivo diagnostic and as X-ray contrast agents, the electromagnetic coupling between three-dimensional gold nanoparticles (AuNPs) is investigated in different concentration. We report on the observation of multipeaks electric field distribution between adjacent gold nanoparticles in the gap distance of AuNPs and on its edges .In this computational and exponential study we examine image reconstruction of electric field distribution occurs due to striking of x-ray on a gold nanoparticles at different concentration, also study the relation between gap distance between neighboring AuNPs. A CST STUDIO program used to calculate the electric field distribution .Electric field images of the gold nanoparticles as contrast agent demonstrate the potential of the approach for detecting the potential of gold nanoparticles in enhancing the image quality.