Abstract
OBJECTIVE: Among the autocrine/paracrine regulators of ovarian function that have been identified, the role of the GnRH/GnRH receptor system in the ovary has received renewed interest. Direct effects of GnRH analogs on the rodent ovary are well established, however a role for GnRH analogs in the primate ovary is less clear. We have demonstrated a rapid and pronounced destruction of primordial follicles in the mouse ovary by short-term treatment with GnRH antagonists (Fertil Steril 2005; 83:1333).
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