Abstract
The effect of glycyrrhetinic acid (18β-glycyrrhetinic acid, GA) on histarnine synthesis and release was investigated in cocultured mast cells with Swiss 3T3 fibroblasts. GA has strong dose dependent inhibitory activity for histamine synthesis and release in cocultured mast cells. GA (50 μM) inhibited about 85% of histidine decarboxylase (HDC) activity. The appearance of cells staining positively with berberine sulfate was also decreased in the presence of GA. It indicates that transdifferentiation of cultured mast cells (CMCs) was also inhibited.
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