Abstract
The effect of two glycolysis inhibitors, sodium fluoride and monoiodoacetate, on the level of cyclic AMP in rat epididymal fat was studied in vitro with cyclic AMP-dependent protein kinases. The large increase (about 200 times in respect of the control level) of cyclic nucleotide concentration induced by noradrenaline plus theophylline, was strongly inhibited by 0·04 M sodium fluoride and by 0·001 M monoiodoacetic acid. The same inhibitors decreased the rate of hormone-induced lipolysis to a similar extent. Cyclic AMP level inside the adipose tissue, not treated with noradrenaline plus theophylline, as well as spontaneous lipolysis, were modified in the same way by fluoride and iodoacetate. These data emphasize the relationship between lipolysis and energy metabolism and, particularly, the importance of the glycolytic pathway for cyclic AMP synthesis.
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