Abstract
Effect of glutamic acid and cysteine on oxidative stress markers in rats
Highlights
The problem of stress, in particular, oxidative stress, and its effects on various functional systems of the organism remains relevant for modern biology and medicine
We focused our attention on two amino acids: L-glutamic acid (Glu) and L-cysteine (Cys)
After that rats from the EPI/Glu and Glu experimental groups intraperitoneally received an aqueous solution of Glu at the dose 750 mg/kg
Summary
The problem of stress, in particular, oxidative stress, and its effects on various functional systems of the organism remains relevant for modern biology and medicine. Severe oxidative stress can lead to the molecular damage to lipids, proteins and DNA, cell dysfunction and cell death [4, 5]. The system of antioxidant protection (enzymatic and nonenzymatic links of the antioxidant defense system) limits the process of free radical oxidation of lipids and proteins. Glu is involved in diverse processes, namely, protein biosynthesis, cofactor production, nitrogen metabolism, stimulates oxidative processes, increasesthe body's resistance to hypoxia, has a membrane-stabilizing effect, normalizes metabolism [6,7,8]. Our goal was to compare the antioxidant effects of Glu, Cys and Glu in combination with Cys on the antioxidant system indicators and the content of lipid peroxidation products in rats under the action of experimental stress
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