Effect of Glucose-Insulin-Potassium infusion on systolic and diastolic functions in patients with chronic ischemic cardiomyopathy

Abstract

Background:Ischemic cardiomyopathy is accompanied with some degrees of decreased metabolism.So,a method to facilitate cellular absorption and use of glucose may promote myocardial function and viability .Glucose,Potassium.Insulin solution(GIK) has been used by some successful results in acute ischemic heart disease and decreases the extent of ischemic zone in myocardium and promote ventricular function.Method and Materials: 25 patients with ischemic cardiomyopathy(EF 0.005) but diastolic function of left ventricle were improved significantly after administration of GIK (p 0.005), but because of metabolic improvements and increased in ventricular function after GIK administration, clinical symptoms were decreased.Conclusion:GIK solution administration(As an accessible and cost-effective agent) may improve ventricular diastolic function and clinical symptoms,so we suggest GIK as an effective therapeutic method in ischemic cardiomyopathy.